Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | SENP1 | Q9P0U3 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348597 | 0.87 | ITGB3 (0.38) | SENP1HTTKMT2ALMNAMAPT | |
| SCHEMBL7348610 | 0.83 | ITGB3 (0.33) | PPARGSENP1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL7343122 | 0.77 | NAMPT (0.42) | KDRSENP1ALDH1A1HPGDHTT | |
| SCHEMBL6776908 | 0.76 | MAPK1 (0.50) | PPARGKDRSENP1ALDH1A1HPGD | |
| SCHEMBL7340645 | 0.74 | ALDH1A1 (0.42) | PPARGKDRSENP1ALDH1A1HPGD | |
| Chlorobenzene SCHEMBL7832714 | 0.74 | KDM4E (0.52) | PPARGKDRALDH1A1HTTMAPK1 | |
| SCHEMBL7350844 | 0.74 | MAPT (0.53) | PPARGKDRSENP1ALDH1A1HPGD | |
| SCHEMBL7856448 | 0.74 | PPARG (0.68) | PPARGKDRSENP1ALDH1A1HPGD | |
| SCHEMBL7823595 | 0.73 | KDM4E (0.53) | KDRALDH1A1HTTRAB9ANPC1 | |
| SCHEMBL7347586 | 0.73 | ITGB3 (0.36) | ALDH1A1HPGDHTTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |