Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 13/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 13/20 | 0.49 |
| ▸ | ABCC8 | Q09428 | 8/20 | 0.49 |
| ▸ | KCNJ8 | Q15842 | 8/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357922 | 0.87 | P2RX7 (0.51) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7348975 | 0.78 | ALDH1A1 (0.43) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7348973 | 0.78 | ALDH1A1 (0.43) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7354876 | 0.77 | P2RX7 (0.51) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7362660 | 0.74 | P2RX7 (0.41) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7359977 | 0.73 | P2RX7 (0.39) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7363333 | 0.72 | MAPKAPK2 (0.40) | ABCC9KCNJ11P2RX7ALDH1A1 | |
| SCHEMBL7356177 | 0.71 | HRH4 (0.54) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7358026 | 0.71 | P2RX7 (0.41) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 | |
| SCHEMBL7357467 | 0.70 | ABCC9 (0.57) | ABCC9KCNJ11ABCC8KCNJ8P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | claimed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | claimed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | claimed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | claimed |
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |