Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.51 |
| ▸ | ABCC9 | O60706 | 8/20 | 0.50 |
| ▸ | KCNJ11 | Q14654 | 8/20 | 0.50 |
| ▸ | ABCC8 | Q09428 | 6/20 | 0.50 |
| ▸ | KCNJ8 | Q15842 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357922 | 0.89 | P2RX7 (0.51) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7348979 | 0.77 | ABCC9 (0.49) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7354870 | 0.75 | P2RX7 (0.41) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7354869 | 0.75 | P2RX7 (0.41) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7362660 | 0.73 | P2RX7 (0.41) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7358026 | 0.71 | P2RX7 (0.41) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7359977 | 0.71 | P2RX7 (0.39) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7350535 | 0.71 | NAMPT (0.62) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL8774811 | 0.71 | ABCC9 (0.69) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7347334 | 0.71 | P2RX7 (0.58) | P2RX7ABCC9KCNJ11ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-B1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | UPJOHN CO (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5567722-A | DIURETICS | THE UPJOHN COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | disclosed |
| WO-1994004500-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS | THE UPJOHN COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |