Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354832 | 0.76 | CUL4A (0.34) | ALDH1A1PARP1SMN1; SMN2KDM4E | |
| SCHEMBL7349449 | 0.68 | GABRA1 (0.37) | GABRA1GABRG2GABRB3GABRA3PTK2 | |
| SCHEMBL28547827 | 0.61 | SMN1; SMN2 (0.42) | PLD1ALDH1A1CRBNSMN1; SMN2KDM4E | |
| SCHEMBL9667506 | 0.60 | ALDH1A1 (0.44) | GABRA1GABRG2GABRB3GABRA3PLD1 | |
| SCHEMBL2567610 | 0.60 | GABRA1 (0.59) | GABRA1GABRG2GABRB3GABRA3PTK2 | |
| SCHEMBL6353295 | 0.60 | PARP1 (0.54) | GABRA1GABRG2GABRB3GABRA3ALDH1A1 | |
| SCHEMBL28552460 | 0.58 | KDM4E (0.38) | PLD1ALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL28536215 | 0.58 | SMN1; SMN2 (0.42) | PLD1ALDH1A1SMN1; SMN2KDM4EGRIN2D | |
| SCHEMBL390365 | 0.58 | PLD1 (0.38) | PLD1ALDH1A1CYP1A2CRBNSMN1; SMN2 | |
| SCHEMBL1140766 | 0.57 | PLD1 (0.47) | PLD1ALDH1A1HSD17B10HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5367077-A | Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands | NEUROGEN CORPORATION (US) | 1994-11-22 | — | — | US | claimed |
| WO-1994025461-A1 | CERTAIN CYCLOALKYL AND AZACYCLOALKYL PYRROLOPYRIDINES; A NEW CLASS OF GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORPORATION (US) | 1994-11-10 | — | — | WO | claimed |
| US-5367077-A | Certain cycloalkyl and azacycloalkyl pyrrolopyridines; a new class of gaba rain receptor ligands | NEUROGEN CORPORATION (US) | 1994-11-22 | — | — | US | disclosed |