Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CRHBP | P24387 | 2/20 | 0.57 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7539973 | 0.85 | GRIA4 (0.54) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2564961 | 0.83 | NPC1 (0.71) | HDAC3HDAC1HDAC2NPC1RAB9A | |
| SCHEMBL7623651 | 0.83 | LMNA (0.60) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL31357785 | 0.81 | CRHBP (0.55) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL7708493 | 0.80 | LMNA (0.56) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7708494 | 0.80 | LMNA (0.56) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8579300 | 0.80 | NR1H4 (0.73) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL261231 | 0.80 | KIF11 (0.54) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL28133906 | 0.79 | MEN1 (0.57) | HDAC3HDAC1HDAC2HDAC4HDAC7 | |
| SCHEMBL2563194 | 0.79 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663416-A | ENZYME INHIBITORS AS ANTIINFLAMMATORY AGENTS OR DERMATITIS TREATMENT | CORTECH INC. | 1997-09-02 | — | — | US | disclosed |
| US-5214191-A | OXIDANT SENSITIVE AND INSENSITIVE AROMATIC ESTERS AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE | CORTECH, INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0465802-A1 | Oxidant sensitive and insensitive aromatic esters as inhibitors of human neutrophil elastase | CORTECH, INC. (US) | 1992-01-15 | — | — | EP | disclosed |
| CN-1056680-A | The preparation method who can be used as the 2-phenylalkanoic acid esters of human leukocytes elastase inhibitor | CORTECH INC (US) | 1991-12-04 | — | — | CN | disclosed |