Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.45 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.45 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.45 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | FASN | P49327 | 1/20 | 0.42 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7359747 | 0.92 | PGR (0.45) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7354439 | 0.87 | CYP1A2 (0.48) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7357010 | 0.86 | GRIK1 (0.47) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL9395755 | 0.83 | PGR (0.54) | GRIA1GRIA2GRIA3GRIA4MEN1 | |
| SCHEMBL7358171 | 0.82 | FEN1 (0.49) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7352345 | 0.81 | CCR2 (0.46) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL9093775 | 0.79 | GRIA1 (0.58) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7353217 | 0.79 | MEN1 (0.51) | GRIA1GRIA2GRIA3GRIA4MEN1 | |
| SCHEMBL7349770 | 0.78 | GRIK1 (0.61) | GRIK1GRIK2GRIK3GRIK4GRIK5 | |
| SCHEMBL7354860 | 0.78 | GRIK1 (0.47) | GRIK1GRIK2GRIK3GRIK4GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |