Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | PARG | Q86W56 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7353213 | 0.92 | PGR (0.46) | NOX4CFTRFEN1KMT2AMEN1 | |
| SCHEMBL7352546 | 0.89 | PARG (0.47) | NOX4CFTRKMT2AMEN1ALDH1A1 | |
| SCHEMBL7358171 | 0.88 | FEN1 (0.49) | NOX4FEN1KMT2AALDH1A1CCR2 | |
| SCHEMBL7361866 | 0.84 | CFTR (0.48) | NOX4CFTRFEN1KMT2AMEN1 | |
| SCHEMBL7356157 | 0.81 | SMN1; SMN2 (0.46) | NOX4CFTRKMT2AMEN1ALDH1A1 | |
| SCHEMBL9395755 | 0.81 | PGR (0.54) | CFTRKMT2AMEN1ALDH1A1 | |
| SCHEMBL7353587 | 0.80 | PGR (0.52) | NOX4FEN1KMT2AALDH1A1CCR2 | |
| SCHEMBL7352345 | 0.79 | CCR2 (0.46) | NOX4FEN1KMT2AMEN1CCR2 | |
| SCHEMBL7361149 | 0.76 | SMN1; SMN2 (0.51) | NOX4CFTRKMT2AMEN1PLA2G2A | |
| SCHEMBL7356210 | 0.75 | TP53 (0.52) | NOX4CFTRFEN1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | claimed |
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |