Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | PRKACG | P22612 | 1/20 | 0.47 |
| ▸ | PRKACB | P22694 | 1/20 | 0.47 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352546 | 0.87 | PARG (0.47) | SMN1; SMN2DCTPP1CFTRPOLBSRC | |
| SCHEMBL7356157 | 0.85 | SMN1; SMN2 (0.46) | SMN1; SMN2DCTPP1CFTRPOLBSRC | |
| SCHEMBL7361866 | 0.84 | CFTR (0.48) | SMN1; SMN2CFTRNOX4MEN1KMT2A | |
| SCHEMBL7354047 | 0.81 | CCR2 (0.47) | SMN1; SMN2DCTPP1CYP1A2POLBSRC | |
| SCHEMBL27605957 | 0.78 | PARG (0.53) | SMN1; SMN2DCTPP1CFTRPOLBSRC | |
| SCHEMBL3184013 | 0.78 | PPARG (0.55) | SMN1; SMN2PLAU | |
| SCHEMBL9478940 | 0.76 | NPC1 (0.50) | SMN1; SMN2DCTPP1POLBMEN1KMT2A | |
| SCHEMBL7349906 | 0.76 | NOX4 (0.45) | CFTRNOX4MEN1KMT2ALMNA | |
| SCHEMBL7356210 | 0.75 | TP53 (0.52) | SMN1; SMN2CYP1A2CFTRPOLBNOX4 | |
| SCHEMBL28946309 | 0.74 | CASP3 (0.66) | SMN1; SMN2POLBMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |