Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | FEN1 | P39748 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.44 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.44 |
| ▸ | GRIK4 | Q16099 | 3/20 | 0.44 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 2/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358171 | 0.92 | FEN1 (0.49) | PGRFEN1TP53NOX4PKM | |
| SCHEMBL7352784 | 0.88 | PGR (0.49) | PGRFEN1NOX4GRIK1GRIK2 | |
| SCHEMBL7353213 | 0.88 | PGR (0.46) | PGRFEN1NOX4ALDH1A1KMT2A | |
| SCHEMBL7356210 | 0.85 | TP53 (0.52) | FEN1TP53NOX4PKMMAPK1 | |
| SCHEMBL7359747 | 0.82 | PGR (0.45) | PGRNOX4GRIK1GRIK2GRIK3 | |
| SCHEMBL7349906 | 0.80 | NOX4 (0.45) | FEN1NOX4CCR2ALDH1A1KMT2A | |
| SCHEMBL12822268 | 0.80 | PKM (0.48) | PGRFEN1TP53NOX4PKM | |
| SCHEMBL7352345 | 0.80 | CCR2 (0.46) | FEN1NOX4GRIK1GRIK2GRIK3 | |
| SCHEMBL9556876 | 0.79 | PGR (0.50) | PGRNOX4GRIK1GRIK2GRIK3 | |
| SCHEMBL9093246 | 0.79 | GRIA1 (0.58) | GRIK1GRIK2GRIK3GRIK4GRIK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6288065-B1 | CENTRAL NERVOUS SYSTEM DISORDERS; PARKINSON*S AND ALZHEIMER*S DISEASE | SCHERING AKTIENGESEELLSCHAFT (DE) | 2001-09-11 | — | — | US | disclosed |
| US-6057304-A | Quinoxaline-phosphonic acid derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-05-02 | — | — | US | disclosed |