Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.70 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295689 | 0.87 | ADRA2A (0.64) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL27394551 | 0.85 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Levodropropizine SCHEMBL29043 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Dropropizine SCHEMBL8379428 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Dropropizine SCHEMBL93975 | 0.83 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL7298012 | 0.82 | KDM4E (0.57) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL16142173 | 0.82 | ADRA2A (0.69) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Dropropizine SCHEMBL27495915 | 0.81 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL7357510 | 0.81 | KDM4E (0.56) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL10153128 | 0.78 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |