Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10153128 | 0.87 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Dropropizine SCHEMBL8379428 | 0.82 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Levodropropizine SCHEMBL29043 | 0.82 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Dropropizine SCHEMBL93975 | 0.82 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL27394551 | 0.82 | ADRA2A (0.66) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL7349909 | 0.82 | ADRA2A (0.70) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL11592740 | 0.81 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL10973337 | 0.81 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| Dropropizine SCHEMBL27495915 | 0.81 | ADRA2A (0.97) | ADRA2AADRA2BADRA2CKMT2AMEN1 | |
| SCHEMBL10572259 | 0.81 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140296249-A1 | 4-PHENYLPIPERAZINE DERIVATIVES WITH FUNCTIONALIZED LINKERS AS DOPAMINE D3 RECEPTOR SELECTIVE LIGANDS AND METHODS OF USE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERV (US) | 2014-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296249-A1 | 4-PHENYLPIPERAZINE DERIVATIVES WITH FUNCTIONALIZED LINKERS AS DOPAMINE D3 RECEPTOR SELECTIVE LIGANDS AND METHODS OF USE | DRD3, DRD2, SLC6A3 | ADRA2A 41/4885ADRA2B 72/4885ADRA2C 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.