Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.52 |
| ▸ | CTSK | P43235 | 3/20 | 0.51 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | CTSS | P25774 | 1/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.48 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.48 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.48 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.48 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.48 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312224 | 1.00 | REN (0.52) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL8759866 | 0.88 | CTSB (0.54) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL9312098 | 0.86 | REN (0.50) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL7293547 | 0.84 | CTSB (0.54) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL7270917 | 0.84 | CTSB (0.54) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL7270921 | 0.84 | CTSB (0.54) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL9312089 | 0.83 | CTSL (0.52) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL9312452 | 0.83 | CTSL (0.52) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL8759915 | 0.81 | CTSB (0.55) | RENCTSKCTSLCTSBCTSS | |
| SCHEMBL8681567 | 0.81 | CTSB (0.51) | RENCTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5342981-A | Substantially isomerically pure hexane or hexene compounds | ABBOTT LABORATORIES (US) | 1994-08-30 | — | — | US | claimed |
| US-5389647-A | A prodrugs as hypotensive agents, treating congestive heart failure, urogenital disorders, vision defects | ABBOTT LABORATORIES (US) | 1995-02-14 | — | — | US | disclosed |
| US-5342981-A | Substantially isomerically pure hexane or hexene compounds | ABBOTT LABORATORIES (US) | 1994-08-30 | — | — | US | disclosed |
| US-5244910-A | Treating hypertension, congestive heart failure | ABBOTT LABORATORIES (US) | 1993-09-14 | — | — | US | disclosed |
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |