Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 16/20 | 0.41 |
| ▸ | CA1 | P00915 | 13/20 | 0.41 |
| ▸ | CA9 | Q16790 | 10/20 | 0.41 |
| ▸ | CA5A | P35218 | 7/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 5/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.39 |
| ▸ | CA12 | O43570 | 5/20 | 0.39 |
| ▸ | CA4 | P22748 | 4/20 | 0.39 |
| ▸ | CA6 | P23280 | 4/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15577721 | 0.87 | PTGES2 (0.43) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL11257470 | 0.85 | CA1 (0.40) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL574790 | 0.84 | CA2 (0.47) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL31726638 | 0.84 | CA2 (0.47) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL10687879 | 0.81 | PTGES2 (0.46) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL30844534 | 0.81 | ALOX5AP (0.38) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL29931968 | 0.77 | ALDH1A1 (0.45) | CA2CA1CA9CA5APTGES2 | |
| SCHEMBL8466777 | 0.75 | TSHR (0.40) | CA2 | |
| SCHEMBL19280573 | 0.75 | IDO1 (0.53) | CA2CA1CA9CA5ACA7 | |
| SCHEMBL10553004 | 0.75 | ADRB2 (0.46) | CA2CA1CA9CA5APTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0904077-A4 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL MYERS SQUIBB CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0904077-A2 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |
| WO-1997029747-A1 | METHODS FOR THE PREPARATION OF BIPHENYL ISOXAZOLE SULFONAMIDES | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-08-21 | — | — | WO | disclosed |