Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7615773 | 0.87 | PDE4B (0.55) | PDE4BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7358235 | 0.81 | PDE4B (0.46) | PDE4BACHEDRD2DRD4 | |
| SCHEMBL9841161 | 0.79 | ACHE (0.55) | PDE4BALDH1A1L3MBTL1ACHETSHR | |
| SCHEMBL24812331 | 0.77 | FDPS (0.49) | PDE4BSMN1; SMN2L3MBTL1DRD2DRD4 | |
| SCHEMBL7322576 | 0.75 | PDE4A (0.55) | PDE4B | |
| SCHEMBL7350036 | 0.74 | PDE4B (0.43) | PDE4B | |
| SCHEMBL14976645 | 0.71 | ALDH1A1 (0.50) | PDE4BALDH1A1SMN1; SMN2L3MBTL1HTT | |
| SCHEMBL22713924 | 0.70 | PDE4B (0.52) | PDE4BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1679244 | 0.70 | ACHE (0.42) | PDE4BALDH1A1ACHETSHRRAB9A | |
| SCHEMBL6584615 | 0.69 | PDE4B (0.60) | PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5994376-A | PHOSPHODIESTERASE INHIBITOR | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-11-30 | — | — | US | disclosed |