Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350408 | 0.83 | PDE1C (0.69) | PDE1CHSD17B10ALDH1A1HPGDGAA | |
| SCHEMBL7342557 | 0.83 | HSD17B10 (0.66) | HSD17B10ALDH1A1HPGDMAPK1GAA | |
| SCHEMBL7344861 | 0.83 | HSD17B10 (0.66) | HSD17B10ALDH1A1HPGDMAPK1GAA | |
| SCHEMBL7348263 | 0.83 | HSD17B10 (0.66) | HSD17B10ALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL7344176 | 0.81 | HSD17B10 (0.66) | HSD17B10ALDH1A1PKMHPGDMAPK1 | |
| SCHEMBL9673018 | 0.80 | CYP2C9 (0.68) | HSD17B10ALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL7347242 | 0.80 | ADORA3 (0.69) | HSD17B10ALDH1A1HPGDMAPK1SMN1; SMN2 | |
| SCHEMBL7343943 | 0.79 | HSD17B10 (0.66) | HSD17B10ALDH1A1PKMHPGDMAPK1 | |
| SCHEMBL7340301 | 0.78 | HSD17B10 (0.67) | HSD17B10ALDH1A1HPGDMAPK1GAA | |
| SCHEMBL7341261 | 0.78 | KDM4E (0.67) | HSD17B10ALDH1A1HPGDGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |