Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | OGG1 | O15527 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354510 | 0.98 | KDM4E (0.50) | KDM4EALDH1A1KMT2ARAB9ARXFP1 | |
| SCHEMBL7345401 | 0.93 | — | — | |
| SCHEMBL80049 | 0.83 | KDM4E (0.71) | KDM4EALDH1A1KMT2ARAB9ARXFP1 | |
| SCHEMBL9356896 | 0.79 | KDM4E (0.52) | KDM4EALDH1A1KMT2ARAB9ARXFP1 | |
| SCHEMBL3489240 | 0.77 | ALDH1A1 (0.38) | KDM4EALDH1A1KMT2ARAB9APOLB | |
| SCHEMBL9356593 | 0.76 | KDM4E (0.48) | KDM4EALDH1A1KMT2ARAB9ARXFP1 | |
| SCHEMBL20621742 | 0.74 | KDM4E (0.73) | KDM4EALDH1A1POLBOGG1GAA | |
| SCHEMBL20621709 | 0.74 | KDM4E (0.73) | KDM4EALDH1A1POLBOGG1GAA | |
| SCHEMBL23906444 | 0.74 | LMNA (0.36) | KDM4EALDH1A1KMT2ARAB9ARXFP1 | |
| SCHEMBL20583677 | 0.74 | KDM4E (0.38) | KDM4EALDH1A1KMT2ARAB9ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |