Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351663 | 0.98 | KDM4E (0.53) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL7345401 | 0.95 | — | — | |
| SCHEMBL80049 | 0.80 | KDM4E (0.71) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL3489240 | 0.79 | ALDH1A1 (0.38) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL9356593 | 0.78 | KDM4E (0.48) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL9356896 | 0.76 | KDM4E (0.52) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL23906444 | 0.76 | LMNA (0.36) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL12539457 | 0.76 | KDM4E (0.60) | KDM4EALDH1A1POLBRAB9AGAA | |
| SCHEMBL20583677 | 0.76 | KDM4E (0.38) | KDM4EALDH1A1POLBKMT2ARAB9A | |
| SCHEMBL18641821 | 0.74 | KDM4E (0.37) | KDM4EALDH1A1POLBKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11090288-B2 | Pyrazole derivatives and their uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2021-08-17 | — | — | US | disclosed |
| US-20190022066-A1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2019-01-24 | — | — | US | disclosed |
| EP-2970138-B1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | CANADIAN BLOOD SERVICES (CA) | 2019-01-16 | — | — | EP | disclosed |
| US-10130609-B2 | Pyrazole derivatives and their uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2018-11-20 | — | — | US | disclosed |
| US-20160022640-A1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | CANADIAN BLOOD SERVICES (CA) | 2016-01-28 | — | — | US | disclosed |
| EP-2970138-A1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | Canadian Blood Services (CA) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014138979-A1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | CANADIAN BLOOD SERVICES (CA) | 2014-09-18 | — | — | WO | disclosed |
| WO-2013067646-A1 | PROCESS FOR THE SYNTHESIS OF BETA-AMINOCARBONYLS | UNIVERSITY OF OTTAWA (CA) | 2013-05-16 | — | — | WO | disclosed |
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10130609-B2 | Pyrazole derivatives and their uses thereof | SSB, HLA-DRB1, U2AF1 | KDM4E 3591/4885ALDH1A1 890/4885POLB 3488/4885 |
| US-11090288-B2 | Pyrazole derivatives and their uses thereof | SSB, HLA-DRB1, U2AF1 | KDM4E 3392/4885ALDH1A1 1195/4885POLB 3953/4885 |
| US-20160022640-A1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | SSB, HLA-DRB1, U2AF1 | KDM4E 3591/4885ALDH1A1 890/4885POLB 3488/4885 |
| US-20190022066-A1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | SSB, HLA-DRB1, U2AF1 | KDM4E 3392/4885ALDH1A1 1195/4885POLB 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.