Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14645765 | 0.82 | HSD17B10 (0.45) | HSD17B10HPGDPOLBKDM4EPTGS1 | |
| SCHEMBL17385951 | 0.79 | IDO1 (0.41) | HSD17B10HPGD | |
| SCHEMBL2742615 | 0.79 | HSD17B10 (0.68) | HSD17B10HPGDPOLBKDM4EPTGS1 | |
| SCHEMBL8015240 | 0.78 | IDO1 (0.43) | HSD17B10 | |
| Bromide SCHEMBL29853696 | 0.77 | HSD17B10 (0.66) | HSD17B10HPGDPOLBKDM4EPTGS1 | |
| SCHEMBL9037504 | 0.76 | POLB (0.65) | HSD17B10HPGDALDH1A1POLBKDM4E | |
| SCHEMBL3594266 | 0.75 | MEN1 (0.47) | HSD17B10HPGDALDH1A1POLBGAA | |
| SCHEMBL6800561 | 0.74 | SMN1; SMN2 (0.40) | HSD17B10HPGDALDH1A1POLBKDM4E | |
| SCHEMBL227654 | 0.74 | CYP1A2 (0.55) | HSD17B10HPGDALDH1A1POLBKDM4E | |
| SCHEMBL9812423 | 0.74 | POLB (0.57) | HSD17B10HPGDALDH1A1POLBMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156761-A | Substituted tetralone derivatives for enhancing cognition | MERCK SHARPE & DOHME LIMITED (GB) | 2000-12-05 | — | — | US | disclosed |