Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21379753 | 0.95 | POLB (0.52) | POLBHSD17B10PDE4BMTNR1AMTNR1B | |
| SCHEMBL9037504 | 0.91 | POLB (0.65) | POLBHSD17B10HDAC1TDP1ALDH1A1 | |
| SCHEMBL27091485 | 0.89 | POLB (0.48) | POLBHSD17B10MTNR1AMTNR1BHDAC1 | |
| SCHEMBL28295631 | 0.85 | POLB (0.55) | POLBHSD17B10PDE4BHDAC1TDP1 | |
| SCHEMBL29167515 | 0.84 | MTNR1A (0.46) | POLBMTNR1AMTNR1BHDAC1 | |
| SCHEMBL11080245 | 0.83 | POLB (0.59) | POLBHSD17B10PDE4BMTNR1AMTNR1B | |
| SCHEMBL11433418 | 0.83 | HSD17B10 (0.67) | POLBHSD17B10MTNR1AMTNR1B | |
| SCHEMBL9671446 | 0.83 | CYP4F2 (0.47) | POLBMTNR1AMTNR1BHDAC1ALDH1A1 | |
| SCHEMBL13647141 | 0.83 | POLB (0.50) | POLBHSD17B10MTNR1AHDAC1CYP1A2 | |
| SCHEMBL30839903 | 0.83 | POLB (0.50) | POLBHSD17B10MTNR1AHDAC1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049564-A | Hypotensive, 5-hydroxytryptamine | ABBOTT LABORATORIES (US) | 1991-09-17 | — | — | US | disclosed |
| US-4618683-A | Tetrahydro-6,7-dimethoxy-1H-benz[e]isoinodolines useful in the treatment of hypertension and as sedatives | ABBOTT LABORATORIES (US) | 1986-10-21 | — | — | US | disclosed |