Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352155 | 0.82 | HSD17B10 (0.48) | HSD17B10KEAP1NFE2L2POLBHPGD | |
| SCHEMBL17385951 | 0.81 | IDO1 (0.41) | HSD17B10HPGDHTR1ASLC6A4 | |
| SCHEMBL8015240 | 0.80 | IDO1 (0.43) | HSD17B10HTR1ASLC6A4 | |
| SCHEMBL2742615 | 0.78 | HSD17B10 (0.68) | HSD17B10POLBHPGDPTGS1AKR1C3 | |
| SCHEMBL3594266 | 0.77 | MEN1 (0.47) | HSD17B10POLBHPGDNPC1MAPT | |
| Bromide SCHEMBL29853696 | 0.76 | HSD17B10 (0.66) | HSD17B10POLBHPGDPTGS1AKR1C3 | |
| SCHEMBL25367856 | 0.76 | IDO1 (0.42) | HSD17B10HTR1ASLC6A4 | |
| SCHEMBL9037504 | 0.75 | POLB (0.65) | HSD17B10POLBHPGDHDAC1KDM4E | |
| SCHEMBL2001551 | 0.75 | HSD17B10 (0.44) | HSD17B10HPGDHTR1ASLC6A4 | |
| SCHEMBL16393647 | 0.74 | RIPK1 (0.47) | HPGDKDM4EPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2746301-B1 | Catalyst | BOREALIS AG (AT) | 2018-05-30 | — | — | EP | disclosed |
| EP-2729479-B1 | CATALYSTS | BOREALIS AG (AT) | 2017-09-06 | — | — | EP | disclosed |
| US-9630980-B2 | Asymmetrical ligands | BOREALIS AG (AT) | 2017-04-25 | — | — | US | disclosed |
| US-9598517-B2 | Catalysts | BOREALIS AG (AT) | 2017-03-21 | — | — | US | disclosed |
| US-20160024123-A1 | Asymmetrical Ligands | BOREALIS AG (AT) | 2016-01-28 | — | — | US | disclosed |
| US-20150344596-A1 | CATALYSTS | BOREALIS AG (AT) | 2015-12-03 | — | — | US | disclosed |
| US-9187583-B2 | Catalysts | BOREALIS AG (AT) | 2015-11-17 | — | — | US | disclosed |
| US-20140221584-A1 | CATALYSTS | BOREALIS AG (AT) | 2014-08-07 | — | — | US | disclosed |
| WO-2014096166-A1 | CATALYSTS | BOREALIS AG (AT) | 2014-06-26 | — | — | WO | disclosed |
| EP-2746301-A1 | Catalyst | Borealis AG (AT) | 2014-06-25 | — | — | EP | disclosed |
| EP-2729479-A1 | CATALYSTS | Borealis AG (AT) | 2014-05-14 | — | — | EP | disclosed |
| WO-2013007650-A1 | CATALYSTS | BOREALIS AG (AT) | 2013-01-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024123-A1 | Asymmetrical Ligands | CCRL2, AR, CCR2 | HSD17B10 694/4885KEAP1 1726/4885NFE2L2 280/4885 |
| US-20150344596-A1 | CATALYSTS | SFN, AP3S1, H1-2 | HSD17B10 1261/4885KEAP1 3093/4885NFE2L2 823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.