SCHEMBL735333

SCHEMBL735333

CC(Nc1ccc(C(F)(F)F)cc1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 2/20 0.53
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
EPHX2 P34913 2/20 0.52
KDM4E B2RXH2 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
TRPV1 Q8NER1 1/20 0.46
MTOR P42345 1/20 0.46
KIF11 P52732 1/20 0.45
TGM2 P21980 1/20 0.45
MMP1 P03956 1/20 0.44
MMP3 P08254 1/20 0.44
MMP7 P09237 1/20 0.44
MMP9 P14780 1/20 0.44
MMP13 P45452 1/20 0.44
DHODH Q02127 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL943656 1.00 MMP2 (0.53) MMP2CA12CA1EPHX2KDM4E
SCHEMBL6495349 0.85 SMN1; SMN2 (0.57) SMN1; SMN2
SCHEMBL6495352 0.85 SMN1; SMN2 (0.57) SMN1; SMN2
SCHEMBL30007225 0.84 NR1H4 (0.53) EPHX2SMN1; SMN2NPC1RAB9ATRPV1
SCHEMBL26687939 0.84 NR1H4 (0.53) EPHX2SMN1; SMN2NPC1RAB9ATRPV1
SCHEMBL1259765 0.83 MMP2 (0.56) MMP2CA12CA1EPHX2NPC1
SCHEMBL9442663 0.83 MMP2 (0.56) MMP2CA12CA1EPHX2NPC1
SCHEMBL11072569 0.83 MMP2 (0.56) MMP2CA12CA1EPHX2NPC1
SCHEMBL6706715 0.82 KDM4E (0.52) KDM4ESMN1; SMN2ALDH1A1
SCHEMBL6706711 0.82 KDM4E (0.52) KDM4ESMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12486302-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2025-12-02 US disclosed
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2022-04-14 US disclosed
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same CDRD VENTURES INC. (CA) 2022-03-22 US disclosed
EP-3941580-A1 D-PEPTIDIC COMPOUNDS FOR VEGF Reflexion Pharmaceuticals, Inc. (US) 2022-01-26 EP disclosed
US-20210061861-A1 D-PEPTIDIC COMPOUNDS FOR VEGF REFLEXION PHARMACEUTICALS, INC. 2021-03-04 US disclosed
WO-2020198074-A1 D-PEPTIDIC COMPOUNDS FOR VEGF REFLEXION PHARMACEUTICALS, INC. (US) 2020-10-01 WO disclosed
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2019-02-07 US disclosed
EP-3414259-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD Ventures Inc. (CA) 2018-12-19 EP disclosed
US-9862837-B2 Antifouling materials YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) 2018-01-09 US disclosed
WO-2017136943-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME CDRD VENTURES INC. (CA) 2017-08-17 WO disclosed
EP-1680139-B1 USE OF SOMATOSTATIN OR ONE OF THE ANALOGS THEREOF FOR PRODUCING A MEDICAMENT SERVING TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN SOD CONSEILS RECH APPLIC (FR) 2007-03-07 EP disclosed
EP-1680139-A2 USE OF SOMATOSTATIN OR ONE OF THE ANALOGS THEREOF FOR PRODUCING A MEDICAMENT SERVING TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) 2006-07-19 EP disclosed
EP-1372688-A4 SOMATOSTATIN ANTAGONISTS UNIV TULANE (US) 2006-06-14 EP disclosed
WO-2005034989-A2 USE OF SOMATOSTATIN OR ONE OF THE ANALOGS THEREOF FOR PRODUCING A MEDICAMENT SERVING TO REGULATE THE OVARIAN FOLLICULAR RESERVE IN NON-MENOPAUSAL WOMEN INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (I.N.S.E.R.N) (FR) 2005-04-21 WO disclosed
EP-1522311-A1 Use of somatostatin or analogs thereof for the preparation of a medicament for the regulation of ovarian follicles reserve by non menopausaled women INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2005-04-13 EP disclosed
US-20040181032-A1 Somatostatin antagonists THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND 2004-09-16 US disclosed
EP-1372688-A2 SOMATOSTATIN ANTAGONISTS The Administrators of The Tulane Educational Fund (US) 2004-01-02 EP disclosed
WO-2002072602-A2 SOMATOSTATIN ANTAGONISTS THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) 2002-09-19 WO disclosed
EP-0773956-A1 PURIFIED FORM OF STREPTOGRAMINES, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-05-21 EP disclosed
WO-1996004298-A1 PURIFIED FORM OF STREPTOGRAMINES, PREPARATION OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1996-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210061861-A1 D-PEPTIDIC COMPOUNDS FOR VEGF VEGFA, KDR, FLT1 MMP2 1230/4885CA12 2749/4885CA1 4481/4885
US-20040181032-A1 Somatostatin antagonists SSTR4, SSTR1, SSTR5 MMP2 4169/4885CA12 2082/4885CA1 1215/4885
US-12486302-B2 Somatostatin receptor antagonist compounds and methods of using the same GPR119, SSTR5, SSTR2 MMP2 3213/4885CA12 635/4885CA1 330/4885
US-11279732-B2 Somatostatin receptor antagonist compounds and methods of using the same GPR119, SSTR5, SSTR2 MMP2 3203/4885CA12 662/4885CA1 325/4885
US-20220112242-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME GPR119, SSTR5, SSTR2 MMP2 3213/4885CA12 635/4885CA1 330/4885
US-20190040102-A1 SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHODS OF USING THE SAME GPR119, SSTR5, SSTR2 MMP2 3203/4885CA12 662/4885CA1 325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.