Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 15/20 | 0.61 |
| ▸ | CTSB | P07858 | 6/20 | 0.61 |
| ▸ | CTSL | P07711 | 6/20 | 0.61 |
| ▸ | CTSK | P43235 | 4/20 | 0.61 |
| ▸ | CTSH | P09668 | 1/20 | 0.61 |
| ▸ | CTSC | P53634 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7354956 | 1.00 | CTSS (0.61) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7026622 | 0.80 | CTSS (0.65) | CTSSCTSBCTSLCTSKCTSH | |
| Bromide SCHEMBL7353567 | 0.79 | CTSL (0.48) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL6448138 | 0.77 | CTSS (0.69) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7403149 | 0.77 | CTSS (0.60) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7353055 | 0.77 | REN (0.46) | CTSSCTSBCTSL | |
| SCHEMBL7353008 | 0.76 | CTSL (1.00) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7352997 | 0.76 | CTSL (1.00) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7352989 | 0.76 | CTSL (1.00) | CTSSCTSBCTSLCTSKCTSH | |
| SCHEMBL7026009 | 0.74 | CTSS (0.75) | CTSSCTSBCTSLCTSKCTSH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6287840-B1 | PEPTIDOMIMETICS; COUPLING, DEBLOCKING; ANTIARTHRITIC, ANTITUMOR, ANTICARCINOGENIC, AND ANTIMETASTASIS AGENTS; MUSCULAR DYSTROPHY, GLOMERULONEPHRITIS, MALARIA, ALZHEIMER*S DISEASE | AXYS PHARMACEUTICALS, INC. | 2001-09-11 | — | — | US | disclosed |
| EP-0756625-A4 | IRREVERSIBLE CYSTEINE PROTEASE INHIBITORS CONTAINING VINYL GROUPS CONJUGATED TO ELECTRON WITHDRAWING GROUPS | ARRIS PHARM CORP (US) | 1999-07-28 | — | — | EP | disclosed |
| EP-0756625-A1 | IRREVERSIBLE CYSTEINE PROTEASE INHIBITORS CONTAINING VINYL GROUPS CONJUGATED TO ELECTRON WITHDRAWING GROUPS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-02-05 | — | — | EP | disclosed |
| WO-1995023222-A1 | IRREVERSIBLE CYSTEINE PROTEASE INHIBITORS CONTAINING VINYL GROUPS CONJUGATED TO ELECTRON WITHDRAWING GROUPS | KHEPRI PHARMACEUTICALS, INC. (US) | 1995-08-31 | — | — | WO | disclosed |