Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7350502 | 0.86 | CCR4 (0.52) | CCR4MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7352314 | 0.83 | LMNA (0.49) | CCR4MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL1735616 | 0.80 | ROCK2 (0.55) | CCR4MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7347625 | 0.79 | GAA (0.54) | CCR4MAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL7348008 | 0.74 | TDP1 (0.52) | MAPTALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL25175478 | 0.73 | ADRA2A (0.70) | CCR4MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL2622218 | 0.72 | CCR4 (0.55) | CCR4MAPTALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL4023574 | 0.70 | MAPT (0.62) | MAPTALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL29826581 | 0.70 | KEAP1 (0.65) | MAPTALDH1A1SMN1; SMN2KMT2ALMNA | |
| SCHEMBL2912624 | 0.70 | KEAP1 (0.65) | MAPTALDH1A1SMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729457-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PROD (US) | 1998-12-23 | — | — | EP | claimed |
| EP-0729457-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-09-04 | — | — | EP | claimed |
| WO-1995014005-A1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-26 | — | — | WO | claimed |
| US-5397790-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-14 | — | — | US | claimed |
| EP-0729457-B1 | DIAMINOCYCLOBUTENE-3,4-DIONES AS SMOOTH MUSCLE RELAXANTS | AMERICAN HOME PROD (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5506252-A | MUSCLE RELAXANTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5403854-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-04-04 | — | — | US | disclosed |
| US-5403853-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-04-04 | — | — | US | disclosed |
| US-5401753-A | Smooth muscle relaxants for urogenital disorders | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-28 | — | — | US | disclosed |
| US-5397790-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-03-14 | — | — | US | disclosed |
| US-5354763-A | Smooth muscle relaxants | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-10-11 | — | — | US | disclosed |