Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 3/20 | 0.60 |
| ▸ | MME | P08473 | 1/20 | 0.58 |
| ▸ | MMP2 | P08253 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507779 | 0.86 | MMP8 (0.62) | MMP8MMEMMP2MMP9 | |
| SCHEMBL8507827 | 0.85 | NPY5R (0.56) | MMP8MME | |
| SCHEMBL14853314 | 0.84 | HDAC1 (0.61) | MMP8MMEMEN1NPC1RAB9A | |
| SCHEMBL8508106 | 0.81 | ERAP2 (0.60) | MMP8 | |
| SCHEMBL7354597 | 0.80 | NPY5R (0.56) | MMP8MME | |
| SCHEMBL8509498 | 0.80 | MMP8 (0.55) | MMP8MME | |
| SCHEMBL28045650 | 0.79 | ALDH1A1 (0.56) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4909594 | 0.79 | MMP8 (0.72) | MMP8MME | |
| SCHEMBL4523811 | 0.74 | ROCK2 (0.62) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4526393 | 0.74 | ROCK2 (0.62) | MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| EP-0911319-A1 | Malonic acid based matrix metalloproteinase inhibitors | Roche Diagnostics GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |