Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 6/20 | 0.48 |
| ▸ | PPARA | Q07869 | 6/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357170 | 0.93 | PPARG (0.46) | PPARGPPARANR3C1NPY5RPPARD | |
| SCHEMBL7350065 | 0.83 | ALOX5 (0.42) | NPY5RPARP10 | |
| SCHEMBL7356441 | 0.81 | EPHX2 (0.42) | PPARGPPARANR3C1NPY5RFFAR1 | |
| SCHEMBL7360385 | 0.81 | PPARG (0.48) | PPARGPPARANR3C1NPY5R | |
| SCHEMBL14210014 | 0.73 | PPARG (0.65) | PPARGPPARAPPARDFFAR1 | |
| SCHEMBL7358523 | 0.73 | MMP12 (0.44) | FFAR1 | |
| SCHEMBL2109313 | 0.73 | EPHX1 (0.68) | PPARGPPARAPPARDEPHX1 | |
| SCHEMBL7347546 | 0.71 | RAB9A (0.46) | PPARGPPARANR3C1NPY5RPARP10 | |
| SCHEMBL6562353 | 0.71 | ALPI (0.61) | PPARGPPARAPPARDEPHX1 | |
| SCHEMBL11439448 | 0.70 | FFAR1 (0.54) | PPARGPPARANPY5RPPARDFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009736-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | Roche Diagnostics GmbH (DE) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011608-A1 | MALONIC ACID BASED MATRIX METALLOPROTEINASE INHIBITORS | ROCHE DIAGNOSTICS GMBH (DE) | 1999-03-11 | — | — | WO | disclosed |