Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352709 | 0.93 | HTR7 (0.45) | DRD4HTR7HTR1ACYP2D6ALDH1A1 | |
| SCHEMBL7345537 | 0.91 | SLC6A5 (0.44) | DRD4HTR7HTR1A | |
| SCHEMBL7346919 | 0.89 | UTS2R (0.42) | DRD4HTR7HTR1AUTS2RKMT2A | |
| SCHEMBL6461236 | 0.86 | HTR7 (0.46) | DRD4HTR7HTR1AUTS2RCARM1 | |
| SCHEMBL7346054 | 0.85 | CNR2 (0.40) | HTR7HTR1AUTS2RLMNAKMT2A | |
| SCHEMBL7351795 | 0.84 | HTR7 (0.44) | DRD4HTR7HTR1AUTS2RCYP2D6 | |
| SCHEMBL7350951 | 0.83 | DRD4 (0.47) | DRD4KMT2ASLC6A12TMEM97MCHR1 | |
| SCHEMBL6462987 | 0.79 | HTR7 (0.47) | HTR7HTR1ACYP2D6CYP2C19LMNA | |
| SCHEMBL6466592 | 0.79 | HTR7 (0.55) | HTR7HTR1ASLC6A12TMEM97MCHR1 | |
| SCHEMBL6457124 | 0.79 | ADRA1D (0.50) | DRD4HTR7HTR1ACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |