Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.77 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.77 |
| ▸ | ACHE | P22303 | 2/20 | 0.75 |
| ▸ | HTR2A | P28223 | 4/20 | 0.66 |
| ▸ | DRD3 | P35462 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.63 |
| ▸ | HRH1 | P35367 | 1/20 | 0.63 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1545344 | 0.91 | DRD2 (0.65) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| Fumaric Acid SCHEMBL1545347 | 0.91 | DRD2 (0.65) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL1545611 | 0.89 | ACHE (0.93) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL7891796 | 0.86 | DRD2 (0.70) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL1545194 | 0.86 | DRD2 (0.70) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL8825093 | 0.86 | DRD2 (0.70) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL22149696 | 0.86 | DRD2 (0.76) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL7973986 | 0.86 | HTR1A (0.69) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL793025 | 0.85 | ACHE (0.80) | DRD2SLC6A4ACHEHTR2ADRD3 | |
| SCHEMBL1544908 | 0.85 | ACHE (0.84) | DRD2SLC6A4ACHEHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612318-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-08-31 | — | — | EP | claimed |
| EP-0542136-A1 | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-19 | — | — | EP | claimed |
| WO-1993009102-A1 | HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1993-05-13 | — | — | WO | claimed |