Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | G6PD | P11413 | 1/20 | 0.42 |
| ▸ | IDE | P14735 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL758951 | 0.81 | LMNA (0.64) | LMNATDP1ENPP2SMN1; SMN2G6PD | |
| SCHEMBL6143116 | 0.80 | LMNA (0.42) | LMNATDP1ALDH1A1PTGS2 | |
| SCHEMBL11144160 | 0.80 | SNCA (0.47) | LMNATDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL12638410 | 0.80 | PTGS2 (0.58) | LMNAALDH1A1PTGS2 | |
| SCHEMBL6182053 | 0.77 | L3MBTL1 (0.61) | LMNATDP1ENPP2SMN1; SMN2G6PD | |
| SCHEMBL24574571 | 0.76 | LMNA (0.42) | LMNATDP1ENPP2SMN1; SMN2G6PD | |
| SCHEMBL29421567 | 0.76 | LMNA (0.49) | LMNATDP1ENPP2SMN1; SMN2G6PD | |
| SCHEMBL4639254 | 0.76 | G6PD (0.60) | LMNATDP1ENPP2SMN1; SMN2G6PD | |
| SCHEMBL2329775 | 0.76 | PTGS2 (0.64) | LMNASMN1; SMN2ALDH1A1PTGS2 | |
| SCHEMBL394533 | 0.76 | LMNA (0.49) | LMNATDP1ENPP2SMN1; SMN2G6PD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054877-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | Du Pont Pharmaceuticals Company (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041246-A1 | NOVEL CYCLIC SULFONAMIDE DERIVATIVES AS METALLOPROTEINASE INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-08-19 | — | — | WO | disclosed |