Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.59 |
| ▸ | CTSS | P25774 | 2/20 | 0.59 |
| ▸ | CTSK | P43235 | 2/20 | 0.59 |
| ▸ | MMP3 | P08254 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11131051 | 1.00 | CTSL (0.59) | CTSLCTSSCTSKMMP3PTPN1 | |
| SCHEMBL10349496 | 0.96 | CTSK (0.57) | CTSLCTSSCTSKMMP3PTPN1 | |
| Hydrochloric Acid SCHEMBL10349702 | 0.96 | CTSK (0.56) | CTSLCTSSCTSKMMP3PTPN1 | |
| SCHEMBL7438832 | 0.95 | MMP1 (0.59) | CTSLCTSSCTSKMMP3PTPN1 | |
| SCHEMBL10705599 | 0.95 | CTSL (0.57) | CTSLCTSSCTSKMMP3PTPN1 | |
| SCHEMBL10349341 | 0.93 | CTSK (0.56) | CTSLCTSSCTSKMMP3PTPN1 | |
| SCHEMBL10706215 | 0.91 | KMT2A (0.49) | CTSLCTSSCTSKMMP3KMT2A | |
| SCHEMBL10707043 | 0.90 | MMP1 (0.57) | CTSLCTSSCTSKMMP3PTPN1 | |
| SCHEMBL10714016 | 0.90 | CTSL (0.50) | CTSLCTSSCTSKMMP3CAPN1 | |
| SCHEMBL10705401 | 0.90 | MMP1 (0.59) | CTSLCTSSCTSKMMP3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6307101-B1 | AMIDES SUBSTITUTED WITH MERCAPTOALCOHOL OR MERCAPTOKETONE GROUPS | CAMPBELL DAVID A (US) | 2001-10-23 | — | — | US | disclosed |
| US-6271232-B1 | INHIBITORS OF METALLOPROTEASES USEFUL IN TREATING DISEASES INVOLVING TISSUE BREAKDOWN, SUCH AS RHEUMATOID ARTHRITIS | AFFYMAX TECHNOLOGIES, N.V. (GB) | 2001-08-07 | — | — | US | disclosed |
| US-6090785-A | USEFUL INHIBITORS OF MATRIX METALLOENDOPROTEINASE-MEDIATED DISEASES INCLUDING OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SEPTIC ARTHRITIS, TUMOR INVASION IN CERTAIN CANCERS, PERIODONTAL DISEASE, PROTEINURIA AND CORONARY THROMBOSIS | MERCK & CO., INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0832100-B1 | NOVEL INHIBITORS OF METALLOPROTEASES AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | AFFYMAX TECH NV (AN) | 2000-04-05 | — | — | EP | disclosed |
| US-5990112-A | 6-MERCAPTOMETHYL-PIPERAZIN-2,5-DIONE DERIVATIVES; USEFUL FOR TREATING OR CONTROLLING DISEASE STATES OR CONDITIONS WHICH INVOLVE TISSUE BREAKDOWN, SUCH AS RHEUMATOID ARTHRITIS | AFFYMAX TECHNOLOGIES N.V. (GB) | 1999-11-23 | — | — | US | disclosed |
| EP-0832100-A4 | NOVEL INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE | AFFYMAX TECH NV (AN) | 1998-09-02 | — | — | EP | disclosed |
| EP-0832100-A1 | NOVEL INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE | AFFYMAX TECHNOLOGIES N.V. (AN) | 1998-04-01 | — | — | EP | disclosed |
| US-5629343-A | INHIBITORS OF METALLOENDOPROTEINASES WHICH DEGRADE CARTILAGE | MERCK & CO., INC. (US) | 1997-05-13 | — | — | US | disclosed |
| WO-1996040738-A1 | NOVEL INHIBITORS OF METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME AND METHODS OF THEIR USE | AFFYMAX TECHNOLOGIES, N.V. (AN) | 1996-12-19 | — | — | WO | disclosed |
| EP-0671911-A4 | CARBOXY-PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS. | MERCK & CO INC (US) | 1996-08-21 | — | — | EP | disclosed |
| EP-0671911-A1 | CARBOXY-PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO. INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5403952-A | Substituted cyclic derivatives as novel antidegenerative agents | MERCK & CO., INC. (US) | 1995-04-04 | — | — | US | disclosed |
| WO-1994012169-A1 | CARBOXY-PEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO., INC. (US) | 1994-06-09 | — | — | WO | disclosed |
| WO-1992021360-A1 | SUBSTITUTED N-CARBOXYALKYLPEPTIDYL DERIVATIVES AS ANTIDEGENERATIVE ACTIVE AGENTS | MERCK & CO., INC. (US) | 1992-12-10 | — | — | WO | disclosed |