Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 10/20 | 0.59 |
| ▸ | MMP3 | P08254 | 5/20 | 0.56 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | MMP9 | P14780 | 2/20 | 0.54 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10707043 | 0.95 | MMP1 (0.57) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL10705401 | 0.95 | MMP1 (0.59) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL11131051 | 0.95 | CTSL (0.59) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL7356544 | 0.95 | CTSL (0.59) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL10825249 | 0.94 | MMP1 (0.57) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL10825200 | 0.93 | PTPN1 (0.57) | MMP1CTSLCTSSCTSKMMP9 | |
| SCHEMBL10349462 | 0.93 | PTPN1 (0.52) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL10349211 | 0.92 | CAPN1 (0.52) | MMP1MMP3MMP2PTPN1 | |
| SCHEMBL10349341 | 0.92 | CTSK (0.56) | MMP1MMP3CTSLCTSSCTSK | |
| SCHEMBL10349496 | 0.92 | CTSK (0.57) | MMP1MMP3CTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126974-B1 | CARBOXYALKYL PEPTIDE DERIVATIVES | G.D. Searle & Co. (US) | 1988-06-15 | — | — | EP | claimed |
| US-4511504-A | COLLAGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1985-04-16 | — | — | US | claimed |
| EP-0126974-A1 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1984-12-05 | — | — | EP | claimed |
| EP-0358660-B1 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE | RES CORP TECHNOLOGIES INC (US) | 1994-05-25 | — | — | EP | disclosed |
| WO-1992022523-A2 | PEPTIDE DERIVATIVES OF COLLAGENASE INHIBITOR | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1992-12-23 | — | — | WO | disclosed |
| EP-0358660-A4 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE | — | 1991-01-09 | — | — | EP | disclosed |
| EP-0159396-B1 | CARBOXYALKYL PEPTIDE DERIVATIVES | G.D. Searle & Co. (US) | 1990-06-27 | — | — | EP | disclosed |
| EP-0358660-A1 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE. | RES CORP TECHNOLOGIES INC (US) | 1990-03-21 | — | — | EP | disclosed |
| WO-1988006890-A1 | SYNTHETIC INHIBITORS OF MAMMALIAN COLLAGENASE | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1988-09-22 | — | — | WO | disclosed |
| EP-0126974-B1 | CARBOXYALKYL PEPTIDE DERIVATIVES | G.D. Searle & Co. (US) | 1988-06-15 | — | — | EP | disclosed |
| US-4568666-A | COLLAGENASE INHIBITORS, ANTIARTJRITIC AGENTS | G. D. SEARLE & CO. (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0159396-A2 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1985-10-30 | — | — | EP | disclosed |
| US-4511504-A | COLLAGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1985-04-16 | — | — | US | disclosed |