Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7358822 | 0.85 | GAA (0.39) | MAPTGAAPOLBNPSR1ALDH1A1 | |
| SCHEMBL16789472 | 0.71 | KDM4E (0.40) | GAAALDH1A1KDM4EJAK2JAK1 | |
| SCHEMBL24147672 | 0.69 | ALDH1A1 (0.38) | MAPTGAAPOLBALDH1A1KDM4E | |
| SCHEMBL15335218 | 0.68 | ALDH1A1 (0.38) | MAPTGAAALDH1A1KDM4EJAK2 | |
| SCHEMBL8177614 | 0.64 | KDM4E (0.43) | MAPTGAAPOLBALDH1A1KDM4E | |
| SCHEMBL14984829 | 0.63 | ALDH1A1 (0.44) | MAPTNPSR1ALDH1A1HPGD | |
| SCHEMBL31520609 | 0.62 | KDM4E (0.43) | MAPTGAAALDH1A1KDM4EHSD17B10 | |
| SCHEMBL27603656 | 0.62 | ALOX15 (0.40) | ALDH1A1KDM4ETDP1HPGDHSD17B10 | |
| SCHEMBL7355574 | 0.62 | HPGD (0.46) | MAPTPOLBALDH1A1KDM4EHPGD | |
| SCHEMBL25391946 | 0.62 | ALDH1A1 (0.35) | MAPTALDH1A1KDM4EHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037343-A | Fibrinogen receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2000-03-14 | — | — | US | disclosed |
| EP-0796098-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1998-04-29 | — | — | EP | disclosed |
| EP-0796098-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-09-24 | — | — | EP | disclosed |
| WO-1996019223-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-06-27 | — | — | WO | disclosed |