Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL497931 | 0.94 | ALDH1A1 (0.54) | ALDH1A1TSHRFDPSHPGDCYP1A2 | |
| SCHEMBL8236716 | 0.82 | ALDH1A1 (0.45) | ALDH1A1TSHRFDPSHPGDCYP1A2 | |
| SCHEMBL20456442 | 0.82 | ALDH1A1 (0.54) | ALDH1A1TSHRFDPSHPGDCYP1A2 | |
| SCHEMBL6584909 | 0.78 | ALDH1A1 (0.58) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| SCHEMBL2432443 | 0.77 | ALDH1A1 (0.66) | ALDH1A1TSHRFDPSHPGDCYP1A2 | |
| SCHEMBL29957052 | 0.77 | ALDH1A1 (0.66) | ALDH1A1TSHRFDPSHPGDCYP1A2 | |
| SCHEMBL9733843 | 0.77 | ALDH1A1 (0.57) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| SCHEMBL2843045 | 0.77 | FDPS (0.61) | ALDH1A1TSHRFDPSHPGDPOLB | |
| SCHEMBL6584890 | 0.77 | ALDH1A1 (0.60) | ALDH1A1TSHRFDPSHPGDAOX1 | |
| SCHEMBL28020395 | 0.75 | RARB (0.54) | ALDH1A1HPGDPOLBAOX1ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| EP-0696276-A1 | N-ACYL SUBSTITUTED PHENYL PIPERIDINES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-02-14 | — | — | EP | disclosed |
| US-5459151-A | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-17 | — | — | US | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |
| WO-1994025437-A1 | N-ACYL SUBSTITUTED PHENYL PIPERIDINES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-10 | — | — | WO | disclosed |