Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 13/20 | 0.47 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9703205 | 0.90 | HTR4 (0.52) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7358522 | 0.83 | HTR4 (0.60) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7294476 | 0.80 | CYP2C9 (0.52) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7300888 | 0.80 | HTR4 (0.77) | CYP2C9PMP22NPSR1MEN1LMNA | |
| Hydrochloric Acid SCHEMBL7291228 | 0.79 | HTR4 (0.76) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7305923 | 0.76 | CNR1 (0.50) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7294480 | 0.75 | CYP2C9 (0.55) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL9703208 | 0.74 | HTR4 (0.61) | CYP2C9PMP22NPSR1MEN1LMNA | |
| SCHEMBL7667532 | 0.73 | HTR3A (0.51) | HTR3A | |
| SCHEMBL16504002 | 0.73 | CYP2C9 (0.66) | CYP2C9PMP22NPSR1MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501322-B1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LTD (GB) | 1996-09-04 | — | — | EP | disclosed |
| EP-0501322-A1 | 3-Piperidinylmethylcarboxylate substituted indoles | GLAXO GROUP LIMITED (GB) | 1992-09-02 | — | — | EP | disclosed |