Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6375685 | 0.82 | ALDH1A1 (0.45) | SMN1; SMN2RAB9AKMT2AGAAALDH1A1 | |
| SCHEMBL13188795 | 0.81 | NPC1 (0.45) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL19007841 | 0.80 | NPC1 (0.47) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL6255909 | 0.80 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL13189129 | 0.79 | NPC1 (0.43) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL15220107 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL9228433 | 0.75 | HTT (0.45) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA | |
| SCHEMBL1494027 | 0.75 | ALDH1A1 (0.44) | SMN1; SMN2RAB9ANPC1KMT2AALDH1A1 | |
| SCHEMBL23364188 | 0.75 | CTSK (0.43) | SMN1; SMN2RAB9ANPC1LMNACA12 | |
| SCHEMBL989681 | 0.74 | CCR6 (0.48) | SMN1; SMN2RAB9ANPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435059-B1 | Retroviral protease inhibitors | HOECHST AG (DE) | 1997-11-05 | — | — | EP | claimed |
| US-5663139-A | VIRICIDE OLIGOPEPTIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-02 | — | — | US | claimed |
| EP-0649426-A1 | INHIBITORS OF RETROVIRAL PROTEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-26 | — | — | EP | claimed |
| WO-1994000461-A1 | INHIBITORS OF RETROVIRAL PROTEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-01-06 | — | — | WO | claimed |
| EP-0435059-A1 | Retroviral protease inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | claimed |
| EP-0428849-A2 | Retroviral protease inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-29 | — | — | EP | claimed |
| US-5712417-A | Inhibitors of retroviral proteases | ABBOTT LABORATORIES (US) | 1998-01-27 | — | — | US | disclosed |
| EP-0435059-B1 | Retroviral protease inhibitors | HOECHST AG (DE) | 1997-11-05 | — | — | EP | disclosed |
| US-5663139-A | VIRICIDE OLIGOPEPTIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-09-02 | — | — | US | disclosed |
| US-5629431-A | Inhibitors of retroviral proteases | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-05-13 | — | — | US | disclosed |
| EP-0649426-A1 | INHIBITORS OF RETROVIRAL PROTEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994000461-A1 | INHIBITORS OF RETROVIRAL PROTEASES | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-01-06 | — | — | WO | disclosed |
| EP-0435059-A1 | Retroviral protease inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |
| EP-0428849-A2 | Retroviral protease inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-29 | — | — | EP | disclosed |