Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360101 | 0.90 | ADAM17 (0.46) | ADAM17TSHRCTSLKMT2ANPC1 | |
| SCHEMBL7356263 | 0.88 | TSHR (0.56) | TSHRCTSLKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL7358942 | 0.87 | KMT2A (0.53) | CTSLKMT2AMEN1L3MBTL1 | |
| SCHEMBL7357544 | 0.87 | ADAM17 (0.45) | ADAM17TSHRCTSLKMT2ANPC1 | |
| SCHEMBL7356782 | 0.82 | GRIA1 (0.48) | KMT2AL3MBTL1 | |
| SCHEMBL7359233 | 0.82 | BRS3 (0.51) | KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8306010 | 0.81 | MMP8 (0.50) | KMT2ANPC1RAB9AL3MBTL1 | |
| SCHEMBL7353908 | 0.80 | LAP3 (0.50) | CTSLKMT2AMEN1L3MBTL1 | |
| SCHEMBL8312360 | 0.80 | KMT2A (0.69) | TSHRKMT2ARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL7356251 | 0.80 | TSHR (0.54) | TSHRCTSLKMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0753003-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995028416-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-26 | — | — | WO | disclosed |