Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SOX18 | P35713 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7401586 | 0.80 | SLC7A5 (0.38) | CYP1A2SLC1A2 | |
| SCHEMBL7400111 | 0.80 | GRM2 (0.52) | CYP1A2 | |
| SCHEMBL7364857 | 0.80 | GRM2 (0.52) | — | |
| SCHEMBL7365726 | 0.80 | GRK2 (0.40) | CYP1A2 | |
| SCHEMBL7368270 | 0.80 | GRM2 (0.52) | CYP1A2SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL7362960 | 0.79 | GRM2 (0.55) | CYP1A2HDAC1 | |
| SCHEMBL7399248 | 0.79 | HSD17B10 (0.45) | SLC1A2 | |
| SCHEMBL7396689 | 0.79 | KMT2A (0.37) | CYP1A2PDPK1SLC1A2 | |
| SCHEMBL7361669 | 0.79 | SMN1; SMN2 (0.42) | SLC1A2 | |
| SCHEMBL7364664 | 0.79 | RARB (0.38) | SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |