Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.38 |
| ▸ | GRM3 | Q14832 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400111 | 0.85 | GRM2 (0.52) | TAAR1GRM2GRM3ALDH1A1CYP1A2 | |
| SCHEMBL7364857 | 0.85 | GRM2 (0.52) | KDM1AGRM2GRM3 | |
| SCHEMBL7396689 | 0.84 | KMT2A (0.37) | CTDSP1GRM2GRM3ALDH1A1CYP1A2 | |
| SCHEMBL7362960 | 0.81 | GRM2 (0.55) | TAAR1GRM2GRM3ALDH1A1CYP1A2 | |
| SCHEMBL7360104 | 0.80 | CYP1A2 (0.46) | CYP1A2 | |
| SCHEMBL7401586 | 0.77 | SLC7A5 (0.38) | GRM2GRM3ALDH1A1CYP1A2 | |
| SCHEMBL7399248 | 0.76 | HSD17B10 (0.45) | GRM2GRM3ALDH1A1FFAR4 | |
| SCHEMBL7361669 | 0.76 | SMN1; SMN2 (0.42) | TDP1L3MBTL1GRM2GRM3ALDH1A1 | |
| SCHEMBL7364664 | 0.76 | RARB (0.38) | GRM2GRM3ALDH1A1 | |
| SCHEMBL7366774 | 0.76 | GRM2 (0.48) | TAAR1GRM2GRM3FFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |