Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 8/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.40 |
| ▸ | AMPD3 | Q01432 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7400111 | 0.85 | GRM2 (0.52) | GRM2GRM3 | |
| SCHEMBL7365726 | 0.85 | GRK2 (0.40) | GRM2GRM3KDM1A | |
| SCHEMBL7364664 | 0.84 | RARB (0.38) | GRM2GRM3FOLH1CYP2C9 | |
| SCHEMBL7362960 | 0.81 | GRM2 (0.55) | GRM2GRM3 | |
| SCHEMBL7360104 | 0.80 | CYP1A2 (0.46) | — | |
| SCHEMBL7401586 | 0.77 | SLC7A5 (0.38) | GRM2GRM3CYP2C9ANPEPENPEP | |
| SCHEMBL7396689 | 0.76 | KMT2A (0.37) | GRM2GRM3CYP2C9 | |
| SCHEMBL7399248 | 0.76 | HSD17B10 (0.45) | GRM2GRM3CYP2C9 | |
| SCHEMBL7361669 | 0.76 | SMN1; SMN2 (0.42) | GRM2GRM3CYP2C9 | |
| SCHEMBL7366774 | 0.76 | GRM2 (0.48) | GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |