Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.55 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.55 |
| ▸ | PTGFR | P43088 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360786 | 0.85 | LDHA (0.47) | PTGFRALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7400111 | 0.84 | GRM2 (0.52) | GRM2GRM3TAAR1CYP1A2ALDH1A1 | |
| SCHEMBL7365726 | 0.81 | GRK2 (0.40) | GRM2GRM3TAAR1CYP1A2ALDH1A1 | |
| SCHEMBL7362412 | 0.80 | HSD17B10 (0.48) | MTNR1AMTNR1BTAAR1AOC3ALDH1A1 | |
| SCHEMBL31748828 | 0.80 | POLB (0.49) | GRM2GRM3PTGFRCYP1A2SIGMAR1 | |
| SCHEMBL7369261 | 0.78 | ALDH1A1 (0.41) | ALDH1A1MEN1KMT2A | |
| SCHEMBL7361669 | 0.76 | SMN1; SMN2 (0.42) | GRM2GRM3PTGFRALDH1A1SMN1; SMN2 | |
| SCHEMBL24440174 | 0.75 | TAAR1 (0.53) | MTNR1AMTNR1BTAAR1CYP1A2HDAC1 | |
| SCHEMBL7365439 | 0.75 | HRH1 (0.43) | ALDH1A1 | |
| SCHEMBL16147991 | 0.74 | SLC1A5 (0.58) | MTNR1AMTNR1BTAAR1CYP1A2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | claimed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | claimed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | claimed |
| EP-0771196-A4 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 1997-09-03 | — | — | EP | disclosed |
| EP-0771196-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1997-05-07 | — | — | EP | disclosed |
| WO-1996007405-A1 | EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |