SCHEMBL7360165

SCHEMBL7360165

c1cc(CCNCCc2ccncc2)ccn1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 2/20 0.54
TDP1 Q9NUW8 1/20 0.48
SIGMAR1 Q99720 2/20 0.48
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GLA P06280 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
HRH1 P35367 2/20 0.46
ROCK1 Q13464 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
KCNH3 Q9ULD8 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20689752 0.91 SIGMAR1 (0.59) LOXL2SIGMAR1ALDH1A1HRH1
SCHEMBL10354595 0.89 LOXL2 (0.61) LOXL2TDP1SIGMAR1ALDH1A1HRH1
SCHEMBL13102158 0.89 ALDH1A1 (0.50) LOXL2TDP1SIGMAR1ALDH1A1KDM4E
SCHEMBL13351099 0.86 LOXL2 (0.46) LOXL2TDP1ALDH1A1KDM4EGLA
SCHEMBL5429971 0.86 ALDH1A1 (0.51) LOXL2TDP1ALDH1A1KDM4EGLA
SCHEMBL10911135 0.85 HRH1 (0.60) LOXL2SIGMAR1HRH1ROCK1
SCHEMBL2566281 0.85 SIGMAR1 (0.47) LOXL2SIGMAR1ALDH1A1HDAC2HDAC8
Hydrochloric Acid SCHEMBL4911691 0.84 ALDH1A1 (0.50) LOXL2TDP1ALDH1A1KDM4EGLA
SCHEMBL7724204 0.84 SIGMAR1 (0.78) SIGMAR1
SCHEMBL2185893 0.84 SIGMAR1 (0.68) SIGMAR1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9260663-B2 Liquid crystal composition, liquid crystal display, and method for producing liquid crystal display JSR CORPORATION (JP) 2016-02-16 US disclosed
US-9260663-B2 Liquid crystal composition, liquid crystal display, and method for producing liquid crystal display JSR CORPORATION (JP) 2016-02-16 US disclosed
US-20150092147-A1 LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY, AND METHOD FOR PRODUCING LIQUID CRYSTAL DISPLAY JSR CORPORATION (JP) 2015-04-02 US disclosed
US-20150092147-A1 LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY, AND METHOD FOR PRODUCING LIQUID CRYSTAL DISPLAY JSR CORPORATION (JP) 2015-04-02 US disclosed
US-6037343-A Fibrinogen receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 2000-03-14 US disclosed
US-6017919-A Compounds and pharmaceutical use thereof JAPAN TOBACCO INC. (JP) 2000-01-25 US disclosed
US-6008214-A Bicyclic compounds SMITHKLINE BEECHAM CORPORATION (US) 1999-12-28 US disclosed
EP-0887340-A1 NOVEL COMPOUNDS AND PHARMACEUTICAL USE THEREOF Japan Tobacco Inc. (JP) 1998-12-30 EP disclosed
EP-0796098-A4 FIBRINOGEN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 1998-04-29 EP disclosed
EP-0796098-A1 FIBRINOGEN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1997-09-24 EP disclosed
EP-0777657-A4 1997-07-16 EP disclosed
EP-0777657-A1 BICYCLIC COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1997-06-11 EP disclosed
WO-1996019223-A1 FIBRINOGEN RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1996-06-27 WO disclosed
WO-1996006087-A1 BICYCLIC COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1996-02-29 WO disclosed
US-4515708-A BETA-PYRIDYLETHYLAMINE EXXON RESEARCH & ENGINEERING CO. (US) 1985-05-07 US disclosed