Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363278 | 0.95 | TACR1 (0.47) | OPRM1OPRD1OPRK1TACR1RAB9A | |
| SCHEMBL7360206 | 0.90 | OPRM1 (0.49) | OPRM1OPRD1OPRK1TACR1CTSL | |
| SCHEMBL7357556 | 0.88 | OPRM1 (0.47) | OPRM1OPRD1OPRK1TACR1CTSL | |
| SCHEMBL7363283 | 0.85 | TACR1 (0.46) | OPRM1OPRD1OPRK1TACR1RAB9A | |
| SCHEMBL7361608 | 0.84 | RAB9A (0.55) | TACR1RAB9A | |
| SCHEMBL7355167 | 0.83 | KMT2A (0.46) | TACR1RAB9AKDM4E | |
| SCHEMBL7361103 | 0.82 | TACR1 (0.44) | OPRM1OPRD1OPRK1TACR1CTSL | |
| SCHEMBL8307193 | 0.79 | TACR1 (0.49) | OPRM1OPRD1OPRK1TACR1RAB9A | |
| SCHEMBL8308617 | 0.74 | TACR1 (0.53) | TACR1RAB9AMMP9 | |
| SCHEMBL7355177 | 0.74 | KMT2A (0.44) | TACR1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753003-B1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-16 | — | — | EP | disclosed |
| US-5668128-A | INHIBITORS OF THIOL PROTEASE, PROPHYLAXIS AND TREATMENT OF BONE DISEASES, OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-09-16 | — | — | US | disclosed |
| EP-0753003-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995028416-A1 | AZIRIDINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-26 | — | — | WO | disclosed |