Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 13/20 | 0.37 |
| ▸ | PDE1A | P54750 | 5/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 5/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PDE6C | P51160 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7446947 | 0.74 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDCYP1A2PDE5A | |
| SCHEMBL7019550 | 0.73 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3671938 | 0.73 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1CPDE6C | |
| SCHEMBL6249380 | 0.73 | PDE5A (0.42) | ALDH1A1KDM4EHPGDPDE5APDE1A | |
| SCHEMBL7964905 | 0.72 | PDE5A (0.38) | ALDH1A1KDM4EHPGDPDE5APDE1A | |
| SCHEMBL7360299 | 0.71 | PDE5A (0.39) | ALDH1A1KDM4EHPGDPDE5APDE1A | |
| SCHEMBL14685954 | 0.70 | KDM4E (0.48) | KDM4EPDE5APDE1AKMT2APDE6C | |
| SCHEMBL7428886 | 0.69 | PDE5A (0.68) | ALDH1A1KDM4EHPGDPDE5APDE1A | |
| SCHEMBL7778185 | 0.69 | PDE5A (0.54) | PDE5APDE1APDE1BPDE1CPDE6C | |
| SCHEMBL5085819 | 0.69 | PDE5A (0.65) | ALDH1A1PDE5AKMT2AMEN1PDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001003644-A9 | PYRAZOLOPYRIMIDINONE DERIVATIVES CONJUGATED TO THIOPHENE MOIETIES OR BENZO [FUSED] 5-MEMBERED HETEROCYCLES FOR ERECTILE DYSFUNCTION | PICOWER INST MED RES (US) | 2001-11-29 | — | — | WO | disclosed |