Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030820 | 0.99 | MITF (0.47) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7360414 | 0.96 | MITF (0.45) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL3203984 | 0.78 | ALDH1A1 (0.44) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7356239 | 0.76 | ALDH1A1 (0.47) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL7284088 | 0.75 | RAD52 (0.50) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL19171858 | 0.71 | MITF (0.50) | MITFALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL26104936 | 0.71 | MITF (0.50) | MITFALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL30279183 | 0.71 | MITF (0.42) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL15611331 | 0.70 | MITF (0.52) | MITFALDH1A1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5468196 | 0.70 | LMNA (0.41) | MITFALDH1A1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117660-A4 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-01-09 | — | — | EP | disclosed |
| EP-1117660-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000018762-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2000-04-06 | — | — | WO | disclosed |