Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846691 | 0.95 | NPC1 (0.46) | NPC1RAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL5786283 | 0.93 | NPC1 (0.44) | NPC1RAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL7049258 | 0.75 | NPC1 (0.40) | NPC1RAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL29963667 | 0.74 | DRD2 (0.38) | LMNA | |
| SCHEMBL7353933 | 0.74 | FFAR4 (0.35) | KMT2ALMNAALDH1A1KDM4E | |
| SCHEMBL2378171 | 0.72 | LMNA (0.60) | NPC1RAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL12301094 | 0.72 | L3MBTL1 (0.35) | KMT2ALMNAMEN1POLB | |
| SCHEMBL7909791 | 0.71 | KMT2A (0.42) | NPC1RAB9AKMT2ALMNAALDH1A1 | |
| SCHEMBL7361816 | 0.70 | KDM4E (0.34) | LMNAALDH1A1KDM4EMAPT | |
| SCHEMBL5784672 | 0.70 | PDE4A (0.40) | NPC1RAB9AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0772610-A1 | DIHYDROBENZOFURANES | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003399-A1 | DIHYDROBENZOFURANES | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1996-02-08 | — | — | WO | disclosed |