Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.53 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.53 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4365952 | 0.87 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL4365955 | 0.87 | GRIA1 (0.54) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8102934 | 0.84 | CES1 (0.39) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL13592440 | 0.84 | GRIA1 (0.36) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL6609831 | 0.84 | MCHR1 (0.39) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6607897 | 0.84 | CYP2C9 (0.39) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8133530 | 0.83 | PTGS2 (0.40) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4370479 | 0.83 | HTR6 (0.47) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL8134987 | 0.82 | SMN1; SMN2 (0.42) | GRIA1GRIA2GRIA3GRIA4ALDH1A1 | |
| SCHEMBL6610756 | 0.81 | KDM1A (0.39) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843945-A | AMPA antagonists and a method of treatment | NEUROSEARCH A/S (DK) | 1998-12-01 | — | — | US | disclosed |
| EP-0698025-B1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH AS (DK) | 1997-12-17 | — | — | EP | disclosed |
| EP-0698025-A1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH A/S (DK) | 1996-02-28 | — | — | EP | disclosed |
| WO-1994026747-A1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH A/S (DK) | 1994-11-24 | — | — | WO | disclosed |