Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 4/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | HTR6 | P50406 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6609831 | 0.88 | MCHR1 (0.39) | MCHR1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL13592440 | 0.88 | GRIA1 (0.36) | CES1ALDH1A1GRIA1GRIA2GRIA3 | |
| SCHEMBL6607897 | 0.88 | CYP2C9 (0.39) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL8134085 | 0.86 | LSS (0.46) | MEN1KMT2AGAAMAPTLMNA | |
| SCHEMBL8103012 | 0.85 | MEN1 (0.38) | MCHR1MEN1KMT2AGAAKDM4E | |
| SCHEMBL7357256 | 0.85 | MEN1 (0.38) | MCHR1MEN1KMT2AGAAKDM4E | |
| SCHEMBL8133530 | 0.85 | PTGS2 (0.40) | HTR6GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6610756 | 0.85 | KDM1A (0.39) | MCHR1DRD2HTR6GRIA1GRIA2 | |
| SCHEMBL4370479 | 0.84 | HTR6 (0.47) | MEN1KMT2AALDH1A1MAPTHTR2C | |
| SCHEMBL7360547 | 0.84 | GRIA1 (0.53) | ALDH1A1TDP1CYP3A4GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781284-B1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH AS (DK) | 2000-01-12 | — | — | EP | disclosed |
| US-5917053-A | INHIBITING GABA RELEASE FROM NEURONS | NEUROSEARCH A/S (DK) | 1999-06-29 | — | — | US | disclosed |
| EP-0698025-B1 | AMPA ANTAGONISTS AND A METHOD OF TREATMENT THEREWITH | NEUROSEARCH AS (DK) | 1997-12-17 | — | — | EP | disclosed |
| EP-0781284-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008494-A1 | INDOLE-2,3-DIONE-3-OXIME DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH A/S (DK) | 1996-03-21 | — | — | WO | disclosed |