Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 3/20 | 0.63 |
| ▸ | CTSL | P07711 | 2/20 | 0.63 |
| ▸ | CTSB | P07858 | 2/20 | 0.63 |
| ▸ | CTSK | P43235 | 2/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.58 |
| ▸ | TACR1 | P25103 | 2/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | MME | P08473 | 1/20 | 0.55 |
| ▸ | ECE1 | P42892 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7314524 | 0.92 | CTSL (0.73) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL9557048 | 0.92 | CTSL (0.73) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL11516887 | 0.90 | CTSS (0.62) | CTSSCTSLCTSBCTSKHDAC8 | |
| SCHEMBL11513382 | 0.90 | MMP9 (0.58) | MMP9MMP8MME | |
| SCHEMBL10521480 | 0.89 | CTSL (0.70) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL31207208 | 0.89 | CTSL (0.70) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL12706406 | 0.87 | BCL2 (0.66) | CTSSCTSLCTSBCTSKHDAC8 | |
| SCHEMBL30999371 | 0.87 | CTSL (0.61) | CTSSCTSLCTSBCTSKHDAC8 | |
| SCHEMBL7350864 | 0.86 | CTSL (0.69) | CTSSCTSLCTSBCTSKTACR1 | |
| SCHEMBL7325767 | 0.86 | CTSL (0.69) | CTSSCTSLCTSBCTSKTACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998025949-A1 | SUBSTITUTED 5-AMINO-1,3,4-THIADIAZOLE-2-THIONES | PROSCRIPT, INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| EP-0845002-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1998-06-03 | — | — | EP | disclosed |
| US-5677282-A | ENZYME INHIBITOR; OSTEOARTHRITIS AND RHEUMATIC DISORDERS | PROSCRIPT, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| WO-1996040745-A2 | AMINO ACID AMIDES OF 5-AMINO-1,3,4-THIADIAZONES AND THEIR USE AS INHIBITORS FOR MATRIX METALLOPROTEINASES | PROSCRIPT, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| US-4213895-A | N-[N-[N-[N-[N-(5-Oxo-L-prolyl)-L-histidyl]-L-tryptophyl]-L-seryl]-L-tyrosyl]glycine azide, an intermediate of the releasing agent of luteinizing hormone (LW) and of follicle stimulating hormone (FSH) | AMERICAN HOME PRODUCTS CORPORATION (US) | 1980-07-22 | — | — | US | disclosed |
| US-4159980-A | Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-07-03 | — | — | US | disclosed |
| US-4159980-A | Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1979-07-03 | — | — | US | disclosed |
| US-3947569-A | Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |
| US-3835108-A | PROCESS FOR PREPARING THE RELEASING HORMONE OF LUTEINIZING HORMONE(LH)AND OF FOLLICLE STIMULATING HORMONE(FSH),SALTS AND COMPOSITIONS THEREOF,AND INTERMEDIATES THEREFOR | AMERICAN HOME PROD | 1974-09-10 | — | — | US | disclosed |