Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7456863 | 0.86 | ADAMTS4 (0.46) | MMP7CYP3A4MMP13GPR119MMP14 | |
| SCHEMBL7358595 | 0.85 | MMP7 (0.38) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL7155176 | 0.78 | PANK3 (0.44) | MMP7ALDH1A1KDM4EMAPTPANK3 | |
| SCHEMBL4818308 | 0.78 | MMP7 (0.60) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL7363493 | 0.77 | KDM4E (0.52) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL14252766 | 0.77 | MMP7 (0.65) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL14252772 | 0.76 | MMP7 (0.49) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL14252796 | 0.76 | MMP7 (0.49) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL14252770 | 0.76 | MMP7 (0.53) | MMP7CYP3A4MMP13ALDH1A1KDM4E | |
| SCHEMBL12463859 | 0.76 | MMP7 (0.59) | MMP7CYP3A4MMP13ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109787-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012478-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |