Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | OGA | O60502 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.31 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360833 | 0.85 | MMP7 (0.46) | MMP7CYP3A4MMP13MMP14KDM4E | |
| SCHEMBL7362584 | 0.80 | GRM5 (0.35) | MMP7CYP3A4MMP13MMP14KDM4E | |
| SCHEMBL4816479 | 0.79 | MMP7 (0.51) | MMP7CYP3A4MMP13MMP14KDM4E | |
| SCHEMBL4809675 | 0.77 | MMP7 (0.45) | MMP7CYP3A4MMP13MMP14ALDH1A1 | |
| SCHEMBL7363493 | 0.75 | KDM4E (0.52) | MMP7CYP3A4MMP13KDM4EALDH1A1 | |
| SCHEMBL14252771 | 0.75 | MMP7 (0.53) | MMP7CYP3A4MMP13MMP14KDM4E | |
| SCHEMBL4809534 | 0.75 | MMP13 (0.39) | MMP7CYP3A4MMP13MMP14KDM4E | |
| SCHEMBL7456863 | 0.73 | ADAMTS4 (0.46) | MMP7CYP3A4MMP13MMP14ADAMTS4 | |
| SCHEMBL14252769 | 0.73 | CYP3A4 (0.48) | MMP7CYP3A4MMP13MMP14KDM4E | |
| SCHEMBL4812342 | 0.72 | KDM4E (0.39) | KDM4EALDH1A1MAPTOGAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109787-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | AstraZeneca AB (SE) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012478-A1 | ARYLPIPERAZINES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS (MMP) | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |