Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9341470 | 0.74 | HTR4 (0.50) | HTR4KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL9342316 | 0.73 | HTR4 (0.48) | HTR4KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL7383392 | 0.69 | KCNH2 (0.51) | KDM4E | |
| SCHEMBL8566824 | 0.69 | HTR4 (0.47) | HTR4KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL7360842 | 0.69 | KCNH2 (0.41) | HTR4KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL7331887 | 0.68 | HRH2 (0.54) | — | |
| SCHEMBL8574546 | 0.68 | HTR4 (0.46) | HTR4KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL9341292 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1PMP22NPSR1 | |
| SCHEMBL7421133 | 0.67 | CHRM1 (0.42) | HTR4 | |
| SCHEMBL7400351 | 0.67 | HTR4 (0.43) | HTR4KDM4EALDH1A1PMP22NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630376-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT 4?-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-28 | — | — | EP | disclosed |
| WO-1993018036-A1 | CONDENSED INDOLE DERIVATIVES AS 5HT4-RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-09-16 | — | — | WO | disclosed |